细胞名称：人前体T细胞急性淋巴细胞白血病细胞J.CaM2
产品规格：T25培养瓶x1；1.5ml冻存管x2
细胞数量：1x10^6；1x10^6
保存温度：37℃；-198℃
运输方式：常温保温运输；干冰运输
安全等级：3
用途限制：仅供科研用途1类
培养体系：DMEM高糖+10%FBS+1%三抗
培养温度：37℃
二氧化碳浓度：5%
简介：人前体T细胞急性淋巴细胞白血病细胞J.CaM2取自14岁男性供体，悬浮培养。
注释
Transformant:NCIt;C129643;Cesium-137 gamma radiation.
Derived from sampling site:Peripheral blood.
基因突变
Heterozygous for BAX p.Glu41Argfs(c.121delG)and p.Glu41Glyfs(c.121dupG)(from parent cell line).
Heterozygous for FBXW7 p.Arg505Cys(c.1513C>T)(from parent cell line).
Heterozygous for INPP5D p.Gln345Ter(c.1033C>T)and c.1097+1065_1097+1112del47(from parent cell line).
Homozygous for MSH2 p.Arg711Ter(c.2131C>T)(from parent cell line).
Homozygous for MSH6 p.Phe1088Serfs*2(c.3261delC)(from parent cell line).
Heterozygous for SYK p.Met34Hisfs*3(c.98_99insG)(from parent cell line).
Heterozygous for TP53 p.Arg196Ter(c.586C>T)(from parent cell line).
HLA信息:/
STR信息:/
参考文献
PubMed=3263650;DOI=10.1073/pnas.85.22.8613
Goldsmith M.A.,Dazin P.F.,Weiss A.
At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor.
Proc.Natl.Acad.Sci.U.S.A.85:8613-8617(1988)
PubMed=9846483;DOI=10.1016/S1074-7613(00)80659-7
Finco T.S.,Kadlecek T.,Zhang W.,Samelson L.E.,Weiss A.
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
Immunity 9:617-626(1998)
